Mulder is part of the CINECA project (Common Infrastructure for National Cohorts in Europe, Canada, and Africa) with 17 partners in Europe and Canada. The CBIO division at UCT leads H3ABionet an NIH-funded Pan African bioinformatics network for H3Africa. Institute of Infectious Disease and Molecular Medicine We work collaboratively with researchers requiring help with general bioinformatics problems and large-scale data analysis. We also develop new algorithms and visualisation tools, including those for pan-genome analysis. We have developed workflows for genomics-related data analysis, including GWAS, NGS and variant calling, RNASeq, 16S rRNA analysis, and WGS metagenomics. In addition to research, we provide bioinformatics services to other researchers in the Institute and beyond. We have also developed a new tool for the analysis of metaproteomic data. We have developed containerized workflows for this analysis as well as for the analysis of whole genome shotgun metagenomics data. The group works with collaborators to analyse microbiome data related to various diseases. The network is building capacity for genomics research in Africa and develops data standards and tools for the data. The group forms the central node for H3ABioNet, the pan African bioinformatics network for H3Africa. Every pair of Z/cloud 2's comes standard with a toe-loop for additional forefoot control and our podiatrist-certified LUVSEAT PU footbed for all-day. We also collaborate with researchers to use GWAS data to study the genetic determinants of disease. Introducing our travel-ready Z/cloud series, featuring our same custom adjustable strap system, performance chacogrip rubber outsole, and a top layer of ultra-soft pu for instant-cushion underfoot. We have developed expertise in GWAS and population genetics and run an imputation service for H3Africa researchers. The group has developed new algorithms and tools for the analysis of African genetic data.
We have also developed a graph-based approach for the analysis of different strains of bacterial pathogens and applied this to Mycobacterium tuberculosis. The group is working on pan genome analysis of Pneumococcal genomes to determine the mechanism of carriage. Nicola Mulder’s main research interests lie in the areas of genomics and its application to human diseases of relevance to Africa. It aims to perform world-class bioinformatics research and provide high quality bioinformatics education, training and services. The Computational Biology (CBIO) Division is the centre of Bioinformatics activities at the University of Cape Town. Head of Division, Computational Biology, Department of Integrative Biomedical Sciences, & Member of the Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town PI H3ABioNet Bioinformatics Network Selected publications | Contact details | Group members | Collaborations
0 kommentar(er)
